People

  • marco.cecchini@nano.cnr.it
  • (+39) 050 509459
  • (+39) 050 509417
  • cecchini_marco

  

Marco Cecchini, PhD

Biophysicist – Group leader

Born in Italy in 1975, he received his Master degree in Physics from the Physics Department of the University of Pisa (Italy) in 1999, and PhD in Condensed Matter Physics from the Scuola Normale Superiore (Italy) in 2006. Currently, he is researcher at the Nanoscience Institute (Pisa, Italy) of the Italian National Research Council (CNR) and Lecturer of Biomaterial Science at the University of Pisa (Biology Department, Laurea Degree Course in Biotechnology).

His main research interests are: development of nanostructured biomaterials for brain pathologies and nerve regeneration; designing, production and testing of surface-acoustic-wave driven microfluidic devices for advanced cell cultures and biosensing.

• M. Agostini, G. Greco, M. Cecchini. A Rayleigh surface acoustic wave (R-SAW) resonator biosensor based on positive and negative reflectors with sub-nanomolar limit of detection. Sensors and Actuators B: Chemical, 254, 1–7 (2018).  

• R. Shilton, M. Travagliati, F. Beltram, M. Cecchini. Nanoliter‐droplet acoustic streaming via ultra high frequency surface acoustic waves. Advanced Materials, 26(29), 4941-4946 (2014).  

• A. Grosso, L. Angella, I. Tonazzini, A. Moscardini, N. Giordano, M. Caleo, S. Rocchiccioli, M. Cecchini. Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease. Neurobiology of Disease, 2019, doi: 10.1016/j.nbd.2019.05.011.  

Ilaria Tonazzini, PhD

Pharmaceutical chemist – Senior post-doc

2018: Individual Fellowship Marie Curie @ Erasmus Medical Center, Dept. Neuroscience, Rotterdam (NL), project NeuroGuide.
2015-2017: Fellow of Fondazione Umberto Veronesi, Istituto Nanoscienze-CNR, Pisa.
2011: EMBO Short-term fellowship at Dept. Neuroscience, Erasmus Medical Center, Rotterdam (NL).
2010-2014: Post-doc position at NEST Scuola Normale Superiore, Pisa (IT).
2007-2009: Post-doc, Istituto per lo Studio dei Materiali Nanostrutturati-CNR, Bologna (IT).
2005-2006: Marie Curie PhD fellowship at the Centre for Molecular Biology and Neuroscience, Oslo (NO).
2005: PhD visiting student at Karolinska Institutet, Stockholm (SE).
2004-2007: PhD in Drug’ Science, University of Pisa.

My main research interest focuses on the study of neuronal environmental sensing in patho-physiological conditions, by means of nano-structured substrates and microfluidics.

• I. Tonazzini, S. Meucci, P. Faraci, F. Beltram, M. Cecchini. Neuronal differentiation on anisotropic nanotopographies: neurite contact guidance tolerance to topographical noiseBiomaterials, 34(25), 6027-6036 (2013).  

• I. Tonazzini, S. Meucci, G.M. Van Woerden, Y. Elgersma, M. Cecchini. Impaired neurite contact guidance in Ubiquitin ligase E3a (Ube3a)-deficient hippocampal neurons on nanostructured substrates. Advanced Healthcare Materials, 5(7), 850-862 (2016).  

• I. Tonazzini, M. Moffa, D. Pisignano, M. Cecchini. Neuregulin-1 functionalization of organic fibers for Schwann cell guidance. Nanotechnology, 28(15), 155303 (2017).  

  • ilaria.tonazzini@sns.it
  • (+39) 050 509434

 

  • matteo.agostini@sns.it
  • (+39) 050 509502
  • (+39) 050 509518
  • mat.ago

  

Matteo Agostini, PhD

Nanotechnology engineer – Post-Doc

Born on 27-Nov-1988 in Latina (Italy). 2013-2017 PhD program in Molecular Biophysics at Scuola Normale Superiore, Pisa (Italy); 2013 MSc in Nanotechnology Engineering at La Sapienza, Rome (Italy).

My research activity is focused on surface-acoustic-waves (SAWs) based biosensors and microfluidic devices for life-sciences applications. 

• M. Agostini, G. Greco, M. Cecchini. A Rayleigh surface acoustic wave (R-SAW) resonator biosensor based on positive and negative reflectors with sub-nanomolar limit of detection. Sensors and Actuators B: Chemical, 254, 1–7 (2018).  

• A. Sonato*, M. Agostini*, G. Ruffato, E. Gazzola, D. Liuni, G. Greco, M. Travagliati, M. Cecchini, F. Romanato. A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor. Lab on a Chip, 16(7), 1224–1233 (2016).  

• R. Shilton, V. Mattoli, M. Travagliati, M. Agostini, A. Desii, F. Beltram, M. Cecchini. Rapid and Controllable Digital Microfluidic Heating by Surface Acoustic Waves. Advanced Functional Materials, 25, 5895–5901 (2015).  

Ambra Del Grosso, MSc

Biologist - Research Fellow

I have just completed the PhD program in biophysical science of the Scuola Normale Superiore of Pisa. I graduated at the University of Pisa in Molecular and Cellular Biology in October 2014 with a thesis based on the development of a TALEN gene therapy approach for a rare disease: Primary ciliary dyskinesia. For my PhD project I’m working on another rare disease, Globoid Cell Leukodistrophy (or Krabbe disease, KD), a lethal childhood leukodystrophy with no cure available to date. In particular, I aim to develop a new nanovector-mediated enzyme replacement therapy for KD and I am also investigating autophagy as a possible pathogenic mechanism involved in the disease.

• A. Del Grosso, S. Antonini, L. Angella, I. Tonazzini, G. Signore, M. Cecchini. Lithium improves cell viability in psychosine-treated MO3.13 human oligodendrocyte cell line via autophagy activation. Journal of Neuroscience Research, 94(11), 1246-1260, 201 (2016).  

• N. Parenti, A. Del Grosso, C. Antoni, M. Cecchini, R. Corradetti, F. Pavone, M. Calamai. Direct imaging of APP proteolysis in living cells. PeerJ, 5, e3086 (2017).  

• M. Lai, M. Pifferi, A. Bush, M. Piras, A. Michelucci, M. Di Cicco, A. Del Grosso, … & S. Franceschi. Gene editing of DNAH11 restores normal cilia motility in primary ciliary dyskinesia. Journal of medical genetics, 53(4), 242-249 (2016).  

  • ambra.delgrosso@sns.it
  • (+39) 050 509502

  

  • gina.greco@sns.it
  • (+39) 050 509502

 

Gina Greco, MSc

Medical physicist – PhD student

PhD student in Biophysical Sciences at Scuola Normale Superiore, Pisa. MSc degree in Physics – curriculum Medical Physics- (2015) and BSc degree in Physics (2013) (Università di Pisa, Italy).

My research is focused on surface acoustic wave (SAW) based biosensors and microfluidic systems for biomedical application.

• G. Greco, M. Agostini, R. Shilton, M. Travagliati, G. Signore, M. Cecchini. Surface acoustic wave (SAW)-enhanced chemical functionalization of gold filmsSensors, 11(17), 2452 (2017).

• A. Sonato*, M. Agostini*, G. Ruffato, E. Gazzola, D. Liuni, G. Greco, M. Travagliati, M. Cecchini, F. Romanato, A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor.  Lab on a Chip, 16(7), 1224–1233 (2016).  

• M. Agostini, G. Greco, M. Cecchini. A Rayleigh surface acoustic wave (R-SAW) resonator biosensor based on positive and negative reflectors with sub-nanomolar limit of detection. Sensors and Actuators B: Chemical, 254, 1–7 (2018).  

Elena Corradi, MSc

Physicist – Research Fellow

I was born in Rome on the 23rd of December 1993. I have studied Physics (curriculum: Matter Physics) at the University of Pisa and I got my Master degree in 2018. As a student, I spent six months in the UK (Harwell Campus, Oxfordshire); there I worked in a start-up and collaborated with the institution “Public Health England”. 

My Master thesis is the result of this experience; it’s focused on 3D real-time modelling of ultraviolet solar exposure. 

At NEST I am fabricating and testing surface acoustic wave sensors.

  • elena.corradi@nano.cnr.it
  • (+39) 050 509502
 
  • roberta.mazzena@sns.it
  • (+39) 050 509502

Roberta Mazzena, MSc

Biotechnologist – PhD student

I’ve taken my bachelor’s degree in Biology, and the master’s degree in Molecular Biotechnology. During my master thesis I’ve worked on a rare disease which affects mainly the females, the PCDH19 related-epilepsy. Now I’m a Ph.D. student in Nanosciences at Scuola Normale Superiore (Pisa).

My research will be focused on biomaterials applied to another rare disorder, the Krabbe disease.

Undergraduated students

Gabriele Parlanti

I’m attending the last year of the master degree in Molecular Biotechnology at the University of Pisa. For my thesis, I’m going to work at the NEST Laboratories on developing a nanovector-mediated enzyme replacement therapy for Krabbe disease (KD).

  • gabriele.parlanti@gmail.com
48d33e9a-7eca-4ddf-90d5-e1ebfc092778

Alessia De Masi

I obtained my BSc degree in Biological Sciences and now I am a master student in Molecular Biotecnology at Scuola Normale Superiore / University of Pisa. I am currently working at NEST for my master thesis, focused on biomaterials for peripheral nerve regeneration.

  • alessia.demasi@sns.it

Maria Laura Vieri

I was born in Florence (Italy), where in 2016 I earned a Bachelor degree in Biotechnology at the University of Florence. Currently I am attending a Master degree in Molecular Biotechnology at the University of Pisa. My thesis work will focus on biosensing.

  • marialaura.vieri@gmail.com