People

  • marco.cecchini@nano.cnr.it
  • (+39) 050 509459
  • (+39) 050 509417
  • cecchini_marco

  

Marco Cecchini, PhD

Biophysicist – Group leader

Born in Italy in 1975, he received his Master degree in Physics from the Physics Department of the University of Pisa (Italy) in 1999, and PhD in Condensed Matter Physics from the Scuola Normale Superiore (Italy) in 2006. Currently, he is researcher at the Nanoscience Institute (Pisa, Italy) of the Italian National Research Council (CNR) and Lecturer of Biomaterial Science at the University of Pisa (Biology Department, Laurea Degree Course in Biotechnology).

His main research interests are: development of nanostructured biomaterials for brain pathologies and nerve regeneration; designing, production and testing of surface-acoustic-wave driven microfluidic devices for advanced cell cultures and biosensing.

• M. Agostini, G. Greco, M. Cecchini. A Rayleigh surface acoustic wave (R-SAW) resonator biosensor based on positive and negative reflectors with sub-nanomolar limit of detection. Sensors and Actuators B: Chemical, 254, 1–7 (2018).  

• R. Shilton, M. Travagliati, F. Beltram, M. Cecchini. Nanoliter‐droplet acoustic streaming via ultra high frequency surface acoustic waves. Advanced Materials, 26(29), 4941-4946 (2014).  

• A. Grosso, L. Angella, I. Tonazzini, A. Moscardini, N. Giordano, M. Caleo, S. Rocchiccioli, M. Cecchini. Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease. Neurobiology of Disease, 2019, doi: 10.1016/j.nbd.2019.05.011.  

Ilaria Tonazzini, PhD

Pharmaceutical chemist – Permanent Research Staff

2019: Researcher at the Nanoscience Institute CNR, Pisa (IT)
2018: Individual Fellowship Marie Curie @ Erasmus Medical Center, Dept. Neuroscience, Rotterdam (NL), project NeuroGuide.
2015-2017: Fellow of Fondazione Umberto Veronesi, Istituto Nanoscienze-CNR, Pisa.
2010-2014: Post-doc position at NEST Scuola Normale Superiore, Pisa (IT).
2007-2009: Post-doc, Istituto per lo Studio dei Materiali Nanostrutturati-CNR, Bologna (IT).
2005-2006: Marie Curie PhD fellowship at the Centre for Molecular Biology and Neuroscience, Oslo (NO).
2005: PhD visiting student at Karolinska Institutet, Stockholm (SE).
2004-2007: PhD in Drug’ Science, University of Pisa.

My main research interest focuses on the study of neuronal environmental sensing in patho-physiological conditions, by means of nano-structured substrates and microfluidics.

• I. Tonazzini, S. Meucci, P. Faraci, F. Beltram, M. Cecchini. Neuronal differentiation on anisotropic nanotopographies: neurite contact guidance tolerance to topographical noiseBiomaterials, 34(25), 6027-6036 (2013).  

• I. Tonazzini, S. Meucci, G.M. Van Woerden, Y. Elgersma, M. Cecchini. Impaired neurite contact guidance in Ubiquitin ligase E3a (Ube3a)-deficient hippocampal neurons on nanostructured substrates. Advanced Healthcare Materials, 5(7), 850-862 (2016).  

• I. Tonazzini, M. Moffa, D. Pisignano, M. Cecchini. Neuregulin-1 functionalization of organic fibers for Schwann cell guidance. Nanotechnology, 28(15), 155303 (2017).  

  • ilaria.tonazzini@sns.it
  • (+39) 050 509434

 

Mariacristina Gagliardi, PhD

Chemical Engineer – Senior Post-Doc

Currently: Postdoctoral fellow at the CNR-NANO Institute, Pisa, Laboratorio NEST, Scuola Normale Superiore

2015-2019: Postdoctoral fellow at the IMT School for Advanced Studies Lucca, Lucca

2013-2015: Postdoctoral fellow at the CMBR @SSSA, Istituto Italiano di Tecnologia, Pontedera, The Biorobotic Institute, Scuola Superiore Sant’Anna

2011-2013: Postdoctoral fellow at the CNI @NEST, Istituto Italiano di Tecnologia, Pisa, Laboratorio NEST, Scuola Normale Superiore

2010-2011: Postdoctoral fellow at the Dept. of Chemical Engineering, Industrial Chemistry and Materials Science, Pisa, University of Pisa

2007-2010: PhD student in Chemical and Materials Engineering at the Dept. of Chemical Engineering, Industrial Chemistry and Materials Science, Pisa, University of Pisa

Research interests: synthesis and development of biodegradable nanocarriers and nanosized polymer-based systems with high molecular recognition properties (MIPs) with applications in drug delivery and sensors

•  M. Gagliardi, A. Bertero, A. Bifone. Molecularly imprinted biodegradable nanoparticlesScientific Reports, 7, 40046 (2017). 

• M. Gagliardi, A. Bertero, G. Bardi, A. Bifone. A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics.  Materials Science and Engineering C, 59, 488-499 (2016).  

• M. Gagliardi, G. Bardi, A. Bifone.Polymeric nanocarriers for the controlled and enhanced delivery of therapeutic agents to the CNS. Therapeutic Delivery, 3, 875–887 (2012). 

  • mariacristina.gagliardi@nano.cnr.it
  • (+39) 050 509502

io-v4-cut
  • matteo.agostini@sns.it
  • (+39) 050 509502
  • (+39) 050 509518
  • mat.ago

  

Matteo Agostini, PhD

Nanotechnology engineer – Post-Doc

Born on 27-Nov-1988 in Latina (Italy). 2013-2017 PhD program in Molecular Biophysics at Scuola Normale Superiore, Pisa (Italy); 2013 MSc in Nanotechnology Engineering at La Sapienza, Rome (Italy).

My research activity is focused on surface-acoustic-waves (SAWs) based biosensors and microfluidic devices for life-sciences applications. 

• M. Agostini, G. Greco, M. Cecchini. A Rayleigh surface acoustic wave (R-SAW) resonator biosensor based on positive and negative reflectors with sub-nanomolar limit of detection. Sensors and Actuators B: Chemical, 254, 1–7 (2018).  

• A. Sonato*, M. Agostini*, G. Ruffato, E. Gazzola, D. Liuni, G. Greco, M. Travagliati, M. Cecchini, F. Romanato. A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor. Lab on a Chip, 16(7), 1224–1233 (2016).  

• R. Shilton, V. Mattoli, M. Travagliati, M. Agostini, A. Desii, F. Beltram, M. Cecchini. Rapid and Controllable Digital Microfluidic Heating by Surface Acoustic Waves. Advanced Functional Materials, 25, 5895–5901 (2015).  

Ambra Del Grosso, MSc

Biologist - Research Fellow

I have just completed the PhD program in biophysical science of the Scuola Normale Superiore of Pisa. I graduated at the University of Pisa in Molecular and Cellular Biology in October 2014 with a thesis based on the development of a TALEN gene therapy approach for a rare disease: Primary ciliary dyskinesia. For my PhD project I’m working on another rare disease, Globoid Cell Leukodistrophy (or Krabbe disease, KD), a lethal childhood leukodystrophy with no cure available to date. In particular, I aim to develop a new nanovector-mediated enzyme replacement therapy for KD and I am also investigating autophagy as a possible pathogenic mechanism involved in the disease.

• A. Del Grosso, S. Antonini, L. Angella, I. Tonazzini, G. Signore, M. Cecchini. Lithium improves cell viability in psychosine-treated MO3.13 human oligodendrocyte cell line via autophagy activation. Journal of Neuroscience Research, 94(11), 1246-1260, 201 (2016).  

• Del Grosso A., Angella L., Tonazzini I., Moscardini A., Giordano N., Caleo M., … and Cecchini, M. Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease. Neurobiology of disease, 129, 195-207 (2019).  

• Galliani M., Santi M., Del Grosso A., Cecchettini A., Santorelli F. M., Hofmann S. L., … and Signore G. Cross-Linked Enzyme Aggregates as Versatile Tool for Enzyme Delivery: Application to Polymeric Nanoparticles. Bioconjugate chemistry, 29(7), 2225-2231 (2018).  

  • ambra.delgrosso@sns.it
  • (+39) 050 509502

  

  • roberta.mazzena@sns.it
  • (+39) 050 509502

Roberta Mazzena, MSc

Biotechnologist – PhD student

I’ve taken my bachelor’s degree in Biology, and the master’s degree in Molecular Biotechnology. During my master thesis I’ve worked on a rare disease which affects mainly the females, the PCDH19 related-epilepsy. Now I’m a Ph.D. student in Nanosciences at Scuola Normale Superiore (Pisa).

My research will be focused on biomaterials applied to another rare disorder, the Krabbe disease.

Elena Corradi, MSc

Physicist – PhD Student

I was born in Rome on the 23rd of December 1993. I have studied Physics (curriculum: Matter Physics) at the University of Pisa and I got my Master degree in 2018. As a student, I spent six months in the UK (Harwell Campus, Oxfordshire); there I worked in a start-up and collaborated with the institution “Public Health England”. 

My Master thesis is the result of this experience; it’s focused on 3D real-time modelling of ultraviolet solar exposure. 

My research is focused on developing innovative surface acoustic wave sensors.

  • elena.corradi@nano.cnr.it
  • (+39) 050 509502
 

Undergraduated students

Francesco Luardelli

I’m attending the last year of the master degree in Physics at the University of Pisa. Thesis Project: Exploring acoustic resonators for biosensing in liquids.

  • luna.f95@live.it

Palumbi Luca

I’m attending the last year of the master degree in Physics at the University of Pisa. Thesis Project: Surface Acoustic Wave devices based on phononic crystals.

  • paluca@autistici.org

Elisa Ottalagana

I’m attending the last year of the master degree in Molecular Biotechnology at the University of Pisa. Thesis Project: Nanoparticle driven enzyme replacement therapy for Krabbe disease.

  • Elisa.Ottalagana@hotmail.it

Luca Scaccini

I’m attending the last year of the master degree in Molecular Biotechnology at the University of Pisa. Thesis Project: Study of the interaction of nanomaterials and nervous system cells.

  • l.scaccini@studenti.unipi.it

Jacopo Menconi

I’m attending the last year of the master degree in Molecular Biotechnology at the University of Pisa. Thesis Project: Chemical functionalization of nano-biosensors.

  • jacopomenconi1@gmail.com