People

  • marco-cecchini@cnr.it
  • (+39) 050 509459
  • (+39) 050 509417
  • cecchini_marco

  

Marco Cecchini, PhD

Physicist – Senior Researcher

Born in Italy in 1975, he earned his Master’s degree in Physics from the Physics Department of the University of Pisa (Italy) in 1999, followed by a PhD in Condensed Matter Physics from the Scuola Normale Superiore (Italy) in 2006. Currently, he holds the position of senior researcher and is a member of the scientific council at the Nanoscience Institute in Pisa, Italy, which is part of the Italian National Research Council (CNR). Additionally, he is a Lecturer of Biomaterial Science within the Biology Department at the University of Pisa for the Laurea Degree Course in Molecular Biotechnology. He is a co-founder of INTA srl, a joint spin-off company of CNR and Scuola Normale Superiore, where he served on the director board and as Chief Technology Officer from 2020 to 2023, and now continues as a scientific advisor.

His primary research interests lie in the development of nanomaterials for brain pathologies and nerve regeneration, as well as in the advancement of surface-acoustic-wave devices for microfluidics and sensing applications.

• M. Agostini, F. Lunardelli,M. Gagliardi, A. Miranda,L. Lamanna, A. Giuliana Luminare, F. Gambineri, M. Lai, M. Pistello, and M. Cecchini. Surface-Acoustic-Wave (SAW) Induced Mixing Enhances the Detection of Viruses: Application to Measles Sensing in Whole Human Saliva with a SAW Lab-On-a-Chip. Advanced Functional Materials , 2201958 (2022). 

• A. Del Grosso, M. Galliani, L. Angella, M. Santi, I. Tonazzini, G. Parlanti, G. Signore, and M. Cecchini. Brain-targeted enzyme-loaded nanoparticles: A breach through the blood-brain barrier for enzyme replacement therapy in Krabbe disease. Science Advances 5, no. 11, eaax7462, DOI: 10.1126/sciadv.aax7462 (2019).  

• M. Gagliardi, M. Agostini, F. Lunardelli, L. Lamanna, A. Miranda, A. Bazzichi, A. G. Luminare, F. Cervelli, F. Gambineri, M. Totaro, M. Lai, G. Maisetta, G. Batoni, M. Pistello, and M Cecchini. Surface Acoustic Wave-based Lab-On-a-Chip for the fast detection of Legionella pneumophila in water. Sensors and Actuators B: Chemical, Volume 379, 15 March 2023, 133299. doi: 10.1016/j.snb.2023.133299.  

Ilaria Tonazzini, PhD

Pharmaceutical chemist – Senior Researcher

2019: Researcher at the Nanoscience Institute CNR, Pisa (IT)
2018: Individual Fellowship Marie Curie @ Erasmus Medical Center, Dept. Neuroscience, Rotterdam (NL), project NeuroGuide.
2015-2017: Fellow of Fondazione Umberto Veronesi, Istituto Nanoscienze-CNR, Pisa.
2010-2014: Post-doc position at NEST Scuola Normale Superiore, Pisa (IT).
2007-2009: Post-doc, Istituto per lo Studio dei Materiali Nanostrutturati-CNR, Bologna (IT).
2005-2006: Marie Curie PhD fellowship at the Centre for Molecular Biology and Neuroscience, Oslo (NO).
2005: PhD visiting student at Karolinska Institutet, Stockholm (SE).
2004-2007: PhD in Drug’ Science, University of Pisa.

My main research interest focuses on the study of neuronal environmental sensing in patho-physiological conditions, by means of nano-structured substrates and microfluidics.

• A. De Masi, I. Tonazzini, C. Masciullo, R. Mezzena, F. Chiellini, D. Puppi, M. Cecchini. Chitosan films for regenerative medicine: fabrication methods and mechanical characterization of nanostructured chitosan films. Biophys Rev, 11, 807–815 (2019).  

• I. Tonazzini, GM Van Woerden, C. Masciullo, E. Mientjes, Y. Elgersma, M. Cecchini . The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons. Molecular Autism, 10, 41 (2019).  

• R. Mezzena, C. Masciullo, S. Antonini, F. Cremisi, M. Scheffner, M. Cecchini, I. Tonazzini. Study of adhesion and migration dynamics in Ubiquitin E3A ligase (UBE3A)-silenced SYSH5Y neuroblastoma cells by micro-structured surfaces. Nanotechnology, 32(2), 025708 (2021).  

  • ilaria.tonazzini@sns.it
  • (+39) 050 509434

 

Mariacristina Gagliardi, PhD

Chemical Engineer – Researcher

Currently: Researcher at the CNR-NANO Institute, Pisa, Laboratorio NEST, Scuola Normale Superiore

2015-2019: Postdoctoral fellow at the IMT School for Advanced Studies Lucca, Lucca

2013-2015: Postdoctoral fellow at the CMBR @SSSA, Istituto Italiano di Tecnologia, Pontedera, The Biorobotic Institute, Scuola Superiore Sant’Anna

2011-2013: Postdoctoral fellow at the CNI @NEST, Istituto Italiano di Tecnologia, Pisa, Laboratorio NEST, Scuola Normale Superiore

2010-2011: Postdoctoral fellow at the Dept. of Chemical Engineering, Industrial Chemistry and Materials Science, Pisa, University of Pisa

2007-2010: PhD student in Chemical and Materials Engineering at the Dept. of Chemical Engineering, Industrial Chemistry and Materials Science, Pisa, University of Pisa

Research interests: synthesis and development of biodegradable nanocarriers and nanosized polymer-based systems with high molecular recognition properties (MIPs) with applications in drug delivery and sensors

•  M. Gagliardi, A. Bertero, A. Bifone. Molecularly imprinted biodegradable nanoparticles. Scientific Reports, 7, 40046 (2017). 

• M. Gagliardi, A. Bertero, G. Bardi, A. Bifone. A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics.  Materials Science and Engineering C, 59, 488-499 (2016).  

• M. Gagliardi, G. Bardi, A. Bifone.Polymeric nanocarriers for the controlled and enhanced delivery of therapeutic agents to the CNS. Therapeutic Delivery, 3, 875–887 (2012). 

  • mariacristina.gagliardi@nano.cnr.it
  • (+39) 050 509502

Ambra Del Grosso, PhD

Biologist - Post-Doc

I have just completed the PhD program in biophysical science of the Scuola Normale Superiore of Pisa. I graduated at the University of Pisa in Molecular and Cellular Biology in October 2014 with a thesis based on the development of a TALEN gene therapy approach for a rare disease: Primary ciliary dyskinesia. 

For my PhD project I’m working on another rare disease, Globoid Cell Leukodistrophy (or Krabbe disease, KD), a lethal childhood leukodystrophy with no cure available to date. In particular, I aim to develop a new nanovector-mediated enzyme replacement therapy for KD and I am also investigating autophagy as a possible pathogenic mechanism involved in the disease.

• A. Del Grosso, S. Antonini, L. Angella, I. Tonazzini, G. Signore, M. Cecchini. Lithium improves cell viability in psychosine-treated MO3.13 human oligodendrocyte cell line via autophagy activation. Journal of Neuroscience Research, 94(11), 1246-1260, 201 (2016).  

• Del Grosso A., Angella L., Tonazzini I., Moscardini A., Giordano N., Caleo M., … and Cecchini, M. Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease. Neurobiology of disease, 129, 195-207 (2019).  

• Galliani M., Santi M., Del Grosso A., Cecchettini A., Santorelli F. M., Hofmann S. L., … and Signore G. Cross-Linked Enzyme Aggregates as Versatile Tool for Enzyme Delivery: Application to Polymeric Nanoparticles. Bioconjugate chemistry, 29(7), 2225-2231 (2018).  

  • ambra.delgrosso@sns.it
  • (+39) 050 509502

  

Sara Carpi, PhD

Pharmaceutical Chemist - Researcher from University of Magna Graecia, CNR-NANO affiliate

From 2020: post-Doc position at NEST, Istituto Nanoscienze-CNR, Pisa.

2017-2020: Researcher (RTDa) in Pharmacology (BIO/14), Department of Pharmacy, University of Pisa (Italy).

2016-2017: Post-Doc position at Department of Pharmacy, University of Pisa (Italy).

2016: EMBO short-term fellowship at the ImmunoViroTherapy Lab, Department of Pharmacy, University of Helsinki (Finland).

2015-2016: Fellowship MSD-SIF.

2012-2015 Ph.D. in Medical Pathophysiology and Pharmacology (Ph.D. Program: “Clinical Pathophysiology and Science of Medicine”), University of Pisa (Italy).

My main research interest focuses on the study of pathogenic mechanisms involved in Krabbe disease (KD) and of the development of a novel platform for Enzyme Replacement Therapy (ERT) for the treatment of KD.

• Carpi S, Polini B, Manera C, Digiacomo M, Salsano JE, Macchia M, Scoditti E, Nieri P. Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells. Front Pharmacol. 2020 Sep 23;11:574317. doi: 10.3389/fphar.2020.574317. eCollection 2020. PMID: 33071785.

• Polini B, Carpi S, Doccini S, Citi V, Martelli A, Feola S, Santorelli FM, Cerullo V, Romanini A, Nieri P. Tumor Suppressor Role of hsa-miR-193a-3p and -5p in Cutaneous Melanoma. Int J Mol Sci., 2020 Aug 27;21(17):6183. doi: 10.3390/ijms21176183. PMID: 32867069.  

• Carpi S, Polini B, Nieri D, Dubbini N, Celi A, Nieri P, Neri T. Expression Analysis of Muscle-Specific miRNAs in Plasma-Derived Extracellular Vesicles from Patients with Chronic Obstructive Pulmonary Disease. Diagnostics, 2020 10(7), 502. doi.org/10.3390/diagnostics10070502.  

  • sara.carpi@cnr.nano.it
  • (+39) 050 509502
  • luca.scaccini@sns.it
  • (+39) --- ------

Luca Scaccini, MSc

Biotechnologist – PhD student

I was born in Arezzo on the 26th of December 1996. I got my bachelor’s degree in Biotechnology (curriculum: biomolecular) at the University of Florence in 2018. I have then obtained the master’s degree in Molecular Biotechnology at the University of Pisa in 2020.

My master’s thesis was about the development and testing of micro-patterned devices, made of a biocompatible and biodegradable material (chitosan), to enhance peripheral nerve regeneration.

I am now a Ph.D. student at the Scuola Normale Superiore in Pisa.

My research is focused in studying a nanoparticles-based treatment for a rare disorder: the Krabbe disease.

  • francesco.lunardelli@sns.it
  • (+39) --- ------

Francesco Lunardelli, MSc

Physicist – PhD student

I was born in La Spezia (SP) on 07/03/1995. I have obtained my bachelor’s degree in Physics at the University of Pisa (Italy) in 2017. Then I got the master’s degree in Condensed Matter Physics at the University of Pisa (Italy) in 2020. From September 2020 to September 2021 I worked as research fellow at CNR-Nano (Pisa, Italy). Now I’m a Ph.D. student in Nanosciences at the Scuola Normale Superiore (Pisa, Italy).

My research is focused on developing biosensors based on surface acoustic wave (SAW) technology, with a particular focus on real-time sensing in liquid environments.

Undergraduated students

Laura Colagiorgio

I’m attending the last year of the master degree in Molecular Biotechnology at the University of Pisa. Thesis Project: Nanoparticle driven enzyme replacement therapy for Krabbe disease.

  • l.colagiorgio@studenti.unipi.it

Giorgia Tori

I’m attending the last year of the master degree in Molecular Biotechnology at the University of Pisa. Thesis Project: Development of surface chemical functionalizations for biosensors.

  • g.tori2@studenti.unipi.it

Martina Niccolini

I’m attending the last year of the master degree in Molecular Biotechnology at the University of Pisa. Thesis Project: Nanoparticles for brain delivery via intranasal administration.

  • m.niccolini5@studenti.unipi.it